Knowledge Center

Category: Endotoxins

Did You Know? USP <797> Sterility and Endotoxin Testing

Did You Know? that USP <797> mandates that all high-risk level compounded sterile pharmaceuticals prepared in groups of more than 25 identical individual, single-dose packages or in multiple-dose vials for administration to multiple patients shall meet a sterility test before they are dispensed or administered and that they shall be tested to ensure that they […]

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LAL Testing for Endoxins: The Use of the Horse Shoe Crab

Last month, we put out an article discussing the importance of the horse shoe crab in relation to testing for endotoxins (click here to access that article). Now, we want to provide you with a video that explains HOW the horse shoe crab is used in relation to testing for these dangerous contaminants; as well […]

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The Horshoe Crab: How Nature and Science are Intertwined to Prevent Pain and Save Lives

Not too long ago, my wife and I took a vacation to Kiawah Island in South Carolina to celebrate her birthday. Early one morning we took a walk along the beach, and after a few hundred yards I came across numerous horseshoe crab exoskeletons lying in the sand. I immediately recognized the arthropod for its […]

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Of Parenterals and Pyroskinetix: Bacterial Endotoxin Testing (BET), Part II

This time around, more about BET (Bacterial Endotoxin Testing) and why we take it so seriously at Hartley Medical Pharmacy. By 2003, as a result of my professional journey through intrathecal drug therapy, I had amassed a great deal more knowledge of and experience with endotoxin testing. I purchased an instrument – PYROSKINETIX — manufactured […]

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Of Hares and Horseshoe Crabs: Bacterial Endotoxin Testing (BET), Part I

Endotoxins are important to me. In addition to impacting the core function of my chosen field – intrathecal drug therapy — they are a singularly fascinating phenomenon. I take them – and Bacterial Endotoxin Testing (BET) — very seriously. Endotoxins are small impurities present in bacteria. They are actually sections of bacterial walls – more […]

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